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Lupron
Lupron (leuprolide
acetate) is an analog of gonadotropin releasing hormone
(GnRH). When given as a subcutaneous (just below the
skin) injection, it "down regulates" the pituitary gland causing it to cease production of FSH and LH. In assisted reproductive technology cycles, physicians take advantage
of the suppressive actions to improve the recruitment
of multiple follicles and prevent premature ovulation.
Side effects are usually short
term. Hot flashes may be felt when the levels of estrogen decrease and will disappear when gonadotropin
injections are started. Lupron should be administered at the same time every day. Lupron comes
in a kit with alcohol wipes, small syringes, and one
container of medicine. The supplies can be carried in a purse and the injection can be quickly and easily administered.
Lupron Injection
Instructions:
- Wash and dry hands thoroughly.
- Assemble supplies: two alcohol wipes,
one tissue, one syringe, medication.
- At first use, remove and discard
plastic cap.
- Clean the Lupron vial with an alcohol
wipe.
- Remove cap from syringe exposing
needle.
- Pull the syringe plunger back until
its tip is at the proper dose mark. Insert needle
straight and firmly into the rubber center of the
vial and push the plunger all the way in.
- Turn the vial upside down.
- Pull the syringe plunger down filling
the medication slightly below the line adding 0.2cc
(or 0.1cc if that is your dose) and remove from the
vial.
- Hold the syringe needle up and flick
with finger to remove any air bubbles.
- Hold the syringe and new alcohol
wipe in the right hand.
- Choose injection site, rotating sides
daily. Pinch the skin gently with the left hand.
- Wipe area then save wipe to wipe
the area again after the injection.
- Holding the syringe like a dart,
perpendicular to the skin, briskly insert small needle
quickly and entirely into the skin.
- Slowly inject all medication, release
the pinch and remove syringe. Cover the area with
alcohol wipe then with tissue.
- When you begin gonadotropin injections,
Lupron dosage will usually decrease to half (0.5mg)
or be discontinued. Medication may continue through
the day of hCG administration or may be terminated
when you begin gonadotropin injections.
Antagon and Cetrotide (ganirelix acetate)
are GnRH antagonists that block the actions of gonadotropin releasing
hormone. These drugs are similar to Lupron
in that Antagon and Cetrotide prevent premature ovulation.
Injections are usually begun later in the
treatment cycle and the duration of treatment is usually three
or four days. Side effects are infrequent, minor, and usually
limited to redness or soreness at the site of the injection.
Both medications come in pre-filled syringes.
- Hold the syringe and alcohol wipe
in the right hand.
- Choose injection site, rotating sides
daily. Pinch the skin gently with the left hand.
- Wipe area then save wipe to wipe the
area again after the injection.
- Holding the syringe like a dart, perpendicular
to the skin, briskly insert small needle quickly and
entirely into the skin.
- Slowly inject all medication, release
the pinch and remove syringe. Cover the area with
alcohol wipe then with tissue.
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